Immunity in Infectious Diseases

Cellular Immunity-Pathogen Interactions in Infectious Diseases

The interactions among host immunity, pathogens, and environment are ever-going process of disease and health. In nature, there is an ongoing equilibrium between infectious agents and their susceptible host organisms. While challenge of immune-competent individuals to low pathogenic strains usually results in elimination of the infectious agent, the other host-pathogen matches generally produce...

Interferon Lambda: Modulating Immunity in Infectious Diseases

Interferon lambdas (IFN-λs; IFNL1-4) modulate immunity in the context of infections and autoimmune diseases, through a network of induced genes. IFN-λs act by binding to the heterodimeric IFN-λ receptor (IFNLR), activating a STAT phosphorylation-dependent signaling cascade. Thereby hundreds of IFN-stimulated genes are induced, which modulate various immune functions via complex forward and feed...

Corticosteroids in Infectious Diseases

Accumulated data based on experiences with curtico,teroids in the management uf infectious disea­ses, have proved that they are very dfective and ,afe drugs provided that are administered properly.  The Corticosteroids arc administered mainly be­c,1usc o; antitoxic, antiimflammatory a11d antiallcrgic effects, the cndotoxius are ncuturalized, generalized body reactions are diminished, damaged t...

Macrophage Cytokines: Involvement in Immunity and Infectious Diseases

The evolution of macrophages has made them primordial for both development and immunity. Their functions range from the shaping of body plans to the ingestion and elimination of apoptotic cells and pathogens. Cytokines are small soluble proteins that confer instructions and mediate communication among immune and non-immune cells. A portfolio of cytokines is central to the role of macrophages as...

New Biomarkers of Innate and Adaptive Immunity in Infectious Diseases